Web-crawling the brain: 3-D nanoscale model of neural circuit created
ScienceDaily (2011-03-10) — Researchers have created a three-dimensional nanoscale model of a neural circuit using electron microscopy. As a result, the researchers can crawl these vast neural networks much as Google crawls web links. … > read full article
Liver, not brain, may be origin of Alzheimer’s plaques
This piece of research ties in with the last two topics concerning hormones as sex hormones play a role in modulating liver function. This helps us remember that we are holistic beings with all our parts working in synergy as one!
ScienceDaily (2011-03-03) — Unexpected results from a new study could completely alter scientists’ ideas about Alzheimer’s disease — pointing to the liver instead of the brain as the source of the “amyloid” that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple approach for Alzheimer’s prevention and treatment.
BHRT For Guys!Megan commented the other day on John’s memory. It’s usually as sharp as a tack, but it’s been slipping lately. He’s forgetting the odd word, grasping for the name of a movie or forgetting what the kids told him they were doing the next day. No, it isn’t Alzheimers or dementia, for a guy its far worse…..andropause, the male equivalent to menopause.
I can’t blame all his memory blips on hormones, after all, most of it is a normal process of pruning neurons and learned selectivity. I mean really, does he need to know the name of that movie? And is it a matter of life or death that he recalls one word? And hey, the kids can always repeat what they said, it’s not as though we didn’t repeat the same things over and over to the kids!
Fact is; there are other things that go along with andropause that affect the brain. Guys, take it as a wake up call to start taking care of your marbles and your muscles!
There’s a new term I’m seeing in the literature on aging and the brain, it’s called ‘successful aging.’ It’s defined as a process of getting older and being healthy. I’m sure a good comedian could have a hey day with the phrase, but I’m no comedian so I’ll leave it alone. Suffice it to say, the goal of growing older is to age successfully, without disease or impediment. Though both menopause and andropause are natural processes, they can sometimes feel like a disease you want to get rid of.
There’s no fixing nature though, she’s perfection already. But, with all that we know about endocrinology, aging and the brain, we certainly can work with her to smooth the process out.
BHRT For Him
Before we dive in to BHRT for men, let’s take a refresher on sex ed, it will make the discussion of hormone decline a bit easier to understand.
Androgenic hormones, namely testosterone and dihydrotestosterone, are what produce male characteristics, like facial hair, muscles, selective hearing and an inability to multitask. Okay, so I’m stretching a bit with the last two. Testosterone is also responsible for sperm production, ability to sustain an erection, and pubertal growth of the penis, scrotum and prostate. It also plays a major role in heart health, sex drive, a sense o f well being, blood sugar control, muscle mass and skin elasticity.
95% of testosterone is produced in the testes, yet it is most active in the brain, heart and skeletal muscles. Testosterone is attracted to androgen receptors in these areas but not all testosterone is available. Some testosterone binds to a protein called Sex Hormone Binding Globulin or SHBG. Once it’s bound to SHBG it becomes too large to enter into cells and therefore cannot connect with the androgen receptors.
SHBG levels in the male body increase from several factors:
• Alcoholic cirrhosis
• Severe liver disease
• High levels of estrogen
• High levels of thyroid hormone
What this means is that even though total testosterone levels look normal, the amount available for cells to use is much lower.
Basically, there are two types of testosterone roaming around the male body. Free testosterone that’s lightly bound to albumin and the SHBG Bound testosterone. The former is also called bio-available testosterone as the albumin can easily become detached making the testosterone available to the cells.
Androgen deficiency or low levels of bio available testosterone are:
• Low libido
• Decreased endurance
• Muscle aches
• Muscle stiffness
• Penis shrinkage
• Sense of humour declines
• Increased sweating
• Decrease in enthusiasm
• Bone loss
Excessive levels of androgens include:
• Increase aggressiveness
• Oily skin
• Increased stroke risk
• High cholesterol
We usually pair estrogen with women, but this hormone is important for a guys well-being too and keeping the right balance between androgens and estrogens is vital for good health.
Estrogen can get quite aggressive with testosterone, vying for receptor sites and weakening the effect of testosterone. And unfortunately, a higher estrogen level also means higher levels of SHBG making it even harder for testosterone to get to the cells.
A major concern is that as we age it becomes more difficult for our body to absorb trace minerals like zinc. Zinc blocks the conversion of androgens to estrogen so a zinc deficiency can just pile on the troubles.
This balance between testosterone and estrogen is sensitive and complex, involving several other compounds and factors. If you are concerned about the consequences of andropause talk to your naturopathic doctor about specific tests. These involve checking the blood for total testosterone and SHBG. From these two tests a simple calculation can determine the amount of testosterone available to tissues. Make sure the blood test occurs in the morning as levels of testosterone can fluctuate throughout the day.
Once your Free Androgen Index has been determined there are several options to choose from if the results show an imbalance. Compounded creams with the addition of testosterone deliver the hormone through the blood stream directly to cells. However, if symptoms do not resolve after treatment, rather than increasing the dosage, check with your naturopathic doctor about looking at estrogen and cortisol levels as both may impede proper assimilation of testosterone.
Mind Medicine Method Prescription
Okay, now you know. What are you going to do about it? Are you concerned about the increased risk of developing Alzheimer’s or dementia from decreased levels of bio available testosterone? Then follow this simple Mind Medicine Prescription:
1. See your naturopathic doctor about your symptoms
2. Get a blood test or salivary hormone test to determine ratios and availability of hormones.
3. Get a prescription from your naturopath for the proper dose and delivery system.
4. Get retested in three months to ensure hormone levels are increasing.
5. If levels have stayed the same, ask your doctor to look at estrogen and cortisol levels.
Interesting information on Serotonin.
ScienceDaily (2011-02-24) — Nearly a third of cases of autism spectrum disorder may have a serotonin component. Scientists now provided further proof by using a serotonin-mimicking medication to improve the social behaviors of a particular type of mice.
#24 Things To Do To Boost Brain Power
Serotonin is to feeling good like cheese is to a grilled cheese sandwich! You just can’t have one without the other. Hard to make a grilled cheese sandwich without the cheese and it’s hard to feel good if your body doesn’t produce or maintain enough serotonin.
Knowing how things work and where they come from is always mind-expanding. Not only does it grow your brain but is also helps with healing work. My clients learn the physiology of their conditions to improve their visualizations and access the healing power of their mind. It creates a faster and more successful treatment outcome. Here’s more information on serotonin and what goes in to its production.
Serotonin comes from one of two places. One is the unlikeliest place, that most people would never suspect, your stomach! Yep, it’s produced in your tummy. About 95% of serotonin is produced there. Scientists are still trying to figure out why! The serotonin in your stomach never sees your brain, as it can’t get past the blood-brain barrier. Some scientists suggest it acts as a hormone and plays a role in bone health.
The other 5% of serotonin is produced in your brain. It’s an important 5%. Especially, for making us feel good. It does need a little help for production though.
You may remember that vitamin B3 is vital to the manufacture of serotonin. But there is another equally important compound, called tryptophan. This amino acid has two important functions:
1. To be converted to niacin by the liver. Check back to Tip #19 for information on B3.
2. And as a precursor for serotonin.
A precursor is a chemical compound or nutrient that, through a metabolic reaction, converts to or produces another compound. Serotonin needs tryptophan. In fact, tryptophan is used therapeutically for raising serotonin levels in cases of insomnia, depression and anxiety.
Research suggests that tryptophan may be useful in the prevention or treatment of:
• Obsessive/compulsive disorder
• Premenstrual syndrome
• Senile dementia and
• Tourette’s syndrome
Tryptophan occurs naturally in protein foods like red meat, dairy products, nuts, seeds, soy products, tuna, shellfish and turkey and also in bananas, but in small amounts compared to other essential amino acids.
There is some controversy whether the amount of tryptophan in food is enough to significantly increase blood levels of tryptophan. In some cases, supplementation with tryptophan may be an option. Unfortunately, it is by prescription only in Canada.
There is another option. The body doesn’t convert tryptophan directly into serotonin. It first changes tryptophan into 5-HTP and then converts the 5-HTP into serotonin. Taking the 5HTP in supplement form is one step closer to serotonin!
Supplementation with a 5-HTP product should be done in partnership with a qualified naturopathic physician. Why? As other nutrients work synergistically to produce and utilize serotonin, it’s important that other levels of nutrients are carefully monitored. If you feel tryptophan may be a better choice for you talk to your naturopathic doctor about prescribing this nutrient.
Mind Medicine Tip
• Increase levels of tryptophan to increase levels of serotonin
• Eat a balanced diet of proteins and,
• If you have trouble sleeping at night, try eating a banana before bed.
Copyright 2011 @ Meza Health Systems, Inc.
The Power of Mind Medicine!